Why do people get Polycystic Kidney Disease?

•  Why is kidney function damaged? Polycystic Kidney Diseaseis a genetic kidney disease, the damage process of which is also a procedure of renal fibrosis. The mutation can relieve factors which can increase the growth of cysts in PKD. With the influence of these factors, the basilar membrane of renal tubules is abnormal. And the growth factors which can lead to renal fibrosis such as EGF、TGF-β、IGF all can promote the proliferation and secretion of epithelial cells. The proliferation of epithelial cells can block the renal tubules, which leads to the retention of liquid, thus forming cysts. In addition, the proliferation can also lead the neck of cysts in the condition of half block. In this case, the liquid can not discharge easily, so the cysts grow up. With the cysts growing, they will press kidney, leading to the insufficiency of blood and oxygen, thus starting renal fibrosis. Once the renal fibrosis starts, a series of renal toxic materials will be relieved such as growth factors PDGF、TGF-β. The Phenotype transformation of renal epithelial cells can be stimulated and generate the myofibroblastlike cells. In this condition, a series of matrix will be secreted and combined.

  With the development of renal fibrosis in PKD, the combination of matrix increases, the degradation decreases, which leads to the unbalance of the combination and degradation of matrix. A large amount of matrix deposits and accumulation, leads to the renal glomerular sclerosis, thus causing the shrink of renal tubules. The renal fibrosis replaces the normal renal unites, which finally leads to the renal fibrosis of PKD eventually.

  In the process when people are suffering from Polycystic Kidney Disease, they have some symptoms such as pain in the back, high blood pressure, hematuria, proteinuria, and so on. To treat it, patients had better choose a Chinese medicine, which can repair the damaged intrinsic cells and increase the immunity.

  Do you have any questions? You can leave a message in the following, or you can describe your symptoms to our expert online free for counseling.Our expert will reply you as soon as possible. Please make sure you have left your correct contact information to us.
  Note: Kidney disease should be treated as soon as possible for enhancing the therapeutic effect and improving your life quality.
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