Mesangial Proliferative Glomerulonephritis is also termed as membranoproliferative glomerulonephritis. Mesangial Proliferative Glomerulonephritis is diagnosed according to pathomorphology. Mesangial Proliferative Glomerulonephritis is prevalent among children and youngsters. It is a group of glomerular disease which is characterized by different degrees of increased mesangial matrix. Mesangial Proliferative Glomerulonephritis is commonly seen among children aged 3 to 15, and the average age is 8. As for adult, the average age is 25 years old. The morbidity of male is slightly higher than that of women. Those who is not slight have no asymptomatic hematuria and (or ) proteinuria and chronic glomerular nephritis. Those who are serious have the symptoms of Nephrotic Syndrome.
30% to 100% of patients with Mesangial Proliferative Glomerulonephritis have microscopic hematuria. 20% to 30% of them suffer from recurrent gross hematuria. Patients whose protein in urine varies from a slight amount to the amount which equals the one of patients with Nephrotic Syndrome. Most patients with Mesangial Proliferative Glomerulonephritis have middle amount of selective proteinuria. 30% of them show slight high blood pressure. At the early stage, most of the patients have normal renal function. At the end stage, 10% to 25% of the patients have declined renal function. In addition, some of them have backache, which may be connected with gross hematuria. The clinical manifestation of Mesangial Proliferative Glomerulonephritis is closely connected with pathological change. Those with obvious diffuse mesangium hyperplasia and typical Nephrotic Syndrome tend to have continuous proteinuria and progressive renal failure. Those with mesangium proliferation and Focal segmental sclerosis can also have renal insufficiency in clinic. And patients with not obvious mesangium proliferation, the disease develops slowly and the prognosis is better than those with obvious mesangium proliferation.
The characteristics of Mesangial Proliferative Glomerulonephritis
The clinical manifestations of Mesangial Proliferative Glomerulonephritis are as follows: firstly, those with Mesangial Proliferative Glomerulonephritis accounts for 50% of those who have had renal biopsy. They take up 30% of those with primary Nephrotic Syndrome. Secondly, males who are suffering from Mesangial Proliferative Glomerulonephritis are more than female. What’s more, youngsters are more likely to suffer from this disease.
Thirdly, 50% percent of them have a history of infection before.
Fourthly, 70% of patients with Mesangial Proliferative Glomerulonephritis have hematuria and sometimes it can be gross hematuria.
Fifthly, the patients condition changes and the morbidity of renal failure and high blood pressure increases slowly.
The pathological characteristics of Mesangial Proliferative Glomerulonephritis
Firstly, the mesangial cells increase.
Secondly, matrix becomes wider.
Thirdly, there is C1q deposition.
Fourthly, there is no proliferation of endothelial cell.
Fifthly, basilemma does not change.
Last but not last, epithelial cell does not change.
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