The manifestations of IgA Nephritis go as follows:
It took the patients several hours to two days to have gross hematuria after infected in the upper respiratory tract. The symptoms last for several hours to several days, some even up to one week. The total number of such patients accounts for about 40% to 50%, slightly higher in children. Some individuals can suffer severe backache and stomach, which may be related to intestinal IgA vasculitis. The other common manifestations of this disease are asymptomatic hematuria or proteinuria, accounting for 30% to 40%. 20% to 25% of the above-mentioned may encounter gross hematuria one or more times during the process.
Nephrotic Syndrome can be found in 5% to 20% of patients, most of whom are children and youngsters. It is a type of DBPH with glomerulosclerosis sometimes. In addition, at times, the phenomenon that mainly refers to mesangial IgA deposition can also appear in the minimal change nephropathy, which is characterized by foot process fusion. Some less than 10% of the patients represent acute renal failure, and all of them can relieve themselves, 20% to 25% of whom are required to be dialyzed duo to the NCGN. In the procedure, patients that are subjected to nitrogen retention of quality form about 25%.
Auxiliary examination
Microscopic hematuria’s urine RBC are chiefly abnormal. 50% of the patients’ serum IgA increases, but this phenomenon has no connection with the disease. The density of lambda light chain in serum IgA increases. It is not worthwhile to test urinary immunoglobulin. Most of the blood complement works well. Some elements or factors of the complement may decrease, which was mainly found in patients who are likely to have family disease.
However, it is not worth diagnosing. In about half patients, the index of IgA fibronection gathered objects may have a transient increase. It contributes to the distinguish of other kidney disease. But it is not beneficial to the progress of itself, which has no diagnostic value as well. 10% to 15% of the patients may have increased IgA circulating immune complex. 32% of patients have increased levels of IgA rheumatoid factor. A number of immunological parameters, including viruses and food antigens, antibodies and Tcell subsets. HLA locus antigens determination results may have changed, but it has no diagnostic values, too. In the biopsy of forearm palmar skin, 50% of the patients can be found deposition of IgA and C3,etc in their capillaries.
Progosis
The disease may have spontaneous remission, which takes up 4% to 20%. Each year, about 1% to 2% of the patients get caught into the end stage of renal failure. It is shown that 80% to 90% of the patients can survive for 10 years, according to the statistic analysis. It is estimated that about 30% of the patients will deteriorate into Uremia. And others will suffer from persistent hematuresis or proteinuria. The elements which caused the poor prognosis are as follows: when they fall ill, they also have suffered from renal insufficiency, protein in urine more than 1.5g/d, high blood pressure, as well as without gross hematuria. It is detected that there exist symptoms in the renal biopsy, such as glomerular interstial fibrosis, violations of glomerular capillary, diffuse hyperplasia and diffuse crescent formation, etc.
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